The Pilot Proficiency Audit of Knowledge, Skills, and Abilities: Adding to the Air Carrier Safety Toolbox

The correlation between air carrier pilot performance and age, total flight time, total airline flight time, and time in current position has not been fully documented. This study observed 62 F/Os in line operations and graded 74 knowledge, skills, and abilities performance variables, utilizing a five-point Likert scale. Knowledge items scored slightly below the referent, with no improvement over time; skills improved with both flight time and years of service; and abilities decline markedly across all independent variables. Changes to pilot training syllabi and techniques, as well as hiring practices, may be indicated. Integrating Pilot Proficiency Audit data into existing LOSA, AQP, ASAP, and FOQA programs can provide a more robust air carrier safety program

Airboat Use and Disturbance of Floating Mat Fen Wetlands in Interior Alaska, U.S.A.

The use of airboats is expanding in Alaska, particularly in the interior. This study describes the nature, magnitude, and distribution of disturbance caused by airboat trails over floating mat fen wetlands in the Tanana Flats near Fairbanks, Alaska. Airphoto interpretation showed over 300 km of airboat trails by 1995, with a 15% expansion of the trail system since 1989. Field sampling was done at 30 trail and adjacent control sites along this trail system to assess changes in hydrology, soils, and vegetation. Water velocities in the trails at two-thirds of the sites were at least an order of magnitude greater than velocities of less than 1.5 cm/sec in the control areas. On average, 30 cm of the 0.5-0.75 m thick floating mat has been removed or eroded by airboat traffic at the sampling locations. Nearly all emergent floating mat vegetation has been destroyed (5% cover remaining on average) so that the trails resemble a highly visible open water stream channel 2-3 m wide through the floating mats. Although the recovery and regrowth potential of floating mats in trails is high, recovery is unlikely in trails with continuing use.En Alaska, l'utilisation des hydroglisseurs est à la hausse, surtout à l'intérieur des terres. Cette étude décrit la nature, l'amplitude et la distribution des perturbations causées par le sillage des hydroglisseurs sur les zones humides de vasières à mattes flottantes situées dans les plaines marécageuses de Tanana près de Fairbanks (en Alaska). L'interprétation de photos a montré que, en 1995, les sillages d'hydroglisseurs s'étendaient sur plus de 300 km, ce qui correspond à une augmentation de 15 p. cent du réseau depuis 1989. On a procédé à un échantillonnage sur le terrain à 30 emplacements de sillages et aires témoins adjacentes le long du réseau en vue d'évaluer les changements dans l'hydrologie, les sols et la végétation. Dans deux tiers des emplacements, la vitesse de l'eau dans les sillages était d'au moins un ordre de grandeur supérieure aux vitesses de moins de 1,5 cm/sec dans les zones témoins. Aux endroits d'échantillonnage, 30 cm en moyenne de la matte flottante épaisse de 0,5 à 0,75 m a été enlevée ou érodée par la circulation de l'hydroglisseur. Presque toute la végétation de la matte flottante émergée a été détruite (il reste en moyenne 5 p. cent du couvert) de sorte que les sillages sont très visibles et forment un chenal d'eau ouverte de 2 à 3 m de large à travers les mattes flottantes. Bien que le potentiel de recouvrement et de repousse des mattes flottantes dans les sillages soit élevé, il est peu probable que ce recouvrement ait lieu dans les sillages qui sont utilisés de façon continue

Evidence for the effects of neonicotinoids used in arable crop production on non-target organisms and concentrations of residues in relevant matrices: a systematic map protocol

Background Neonicotinoid insecticides (NNIs) have been routinely used in arable crop protection since their development in the early 1990s. These insecticides have been subject to the same registration procedures as other groups of pesticides, thus meet the same environmental hazard standards as all crop protection products. However, during the last 10 years the debate regarding their possible detrimental impact on non-target organisms, particularly pollinators, has become increasingly contentious and widely debated. Against this background, legislators and politicians in some countries, have been faced with a need to make decisions on the future registration of some or all of this class of insecticides, based on published evidence that in some areas is incomplete or limited in extent. This has created much concern in agricultural communities that consider that the withdrawal of these insecticides is likely to have significant negative economic, socio-economic and environmental consequences. Methods The proposed systematic map aims to address the following primary question: What is the available evidence for the effects of neonicotinoids used in arable crop production on non-target organisms and concentrations of residues in relevant matrices? The primary question will be divided into two sub-questions to gather research literature for (1) the effect of NNIs on non-target organisms (2) the occurrence of concentrations of NNIs in matrices of relevance to non-target organisms (i.e. exposure routes). The systematic map will focus on NNIs used in arable crop production: imidacloprid, clothianidin, thiamethoxam, acetamiprid, thiacloprid and dinotefuran. Separate inclusion criteria have been developed for each sub-question. Traditional academic and grey literature will be searched for in English language and a searchable databases containing extracted meta-data from relevant included studies will be developed

Pulsation Analysis In Positive Displacement Pump Systems Using Waterhammer, Modal And Animation Software

TutorialHigh-pressure and flow metering systems often include a positive displacement (PD) pump and a network of piping and process equipment. Steady state pressure and flow dynamics (pulsation) is a common problem in PD pump systems, which can cause high vibration, fatigue failures, frequent maintenance outages, and flow uniformity or product quality problems. A number of engineering consulting firms have developed computational capabilities in pulsation, which they offer in the form of client services, but these are expensive. So too is the limited amount of commercial pulsation-specific software. This paper describes a methodology to computer model pulsation using a combination of general-purpose and readily available, widely used software. Waterhammer Software -- Normally used to simulate transients, if periodic flow forcing is modeled, the transients die out, and leave only the steady-state pulsation. Modal Software -- Frequency analysis of high-speed digital time history data can be done with many software platforms, including those for Experimental Modal Analysis (EMA), Data Acquisition, or general-purpose Statistical/Mathematical modeling. Animation Software -- Typically included with EMA software, animation is not necessary, but is useful to visually show pressure and flow response across the system at acoustic natural frequencies and for PD pump flow forcing. An example problem shows how to efficiently model complex systems to determine acoustic natural frequencies, mode shapes, and pulsation response to PD pump forcing. Fundamentals of waterhammer and important modeling techniques are discussed. An introduction to EMA and digital signal processing is also provided

A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo

Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the central event in initiating adaptive immunity. The accepted dogma is that this occurs by stimulating local activation and antigen acquisition by dendritic cells, with subsequent lymph node migration, however the generalizability of this mechanism is unclear. Here we show that in some circumstances antigen can bypass the injection site inflammatory response, draining freely and rapidly to the lymph nodes where it interacts with subcapsular sinus (SCS) macrophages resulting in their death. Debris from these dying SCS macrophages is internalized by monocytes recruited from the circulation. This coordinated response leads to antigen presentation by monocytes and interactions with naïve CD4 T cells that can drive the initiation of T cell and B cell responses. These studies demonstrate an entirely novel pathway leading to initiation of adaptive immune responses in vivo

Configuration development study of the X-24C hypersonic research airplane

Bottom line results were made of a three-phase study to determine the feasibility of designing, building, and operating, and maintaining an air-launched high performance aircraft capable of cruising at speeds up to Mach 8 for short durations. The results show that Lockalloy heat-sink structure affords the capability for a 'work-horse' vehicle which can serve as an excellent platform for this research. It was further concluded that the performance of a blended wing body configuration surpassed that of a lifting body design for typical X-24C missions. The cost of a two vehicle program, less engines, B-52 modification and contractor support after delivery, can be kept within $70M (in Jan. 1976 dollars)

N-Terminal Pro–B-Type Natriuretic Peptide in the Emergency Department: The ICON-RELOADED Study

Background Contemporary reconsideration of diagnostic N-terminal pro–B-type natriuretic peptide (NT-proBNP) cutoffs for diagnosis of heart failure (HF) is needed. Objectives This study sought to evaluate the diagnostic performance of NT-proBNP for acute HF in patients with dyspnea in the emergency department (ED) setting. Methods Dyspneic patients presenting to 19 EDs in North America were enrolled and had blood drawn for subsequent NT-proBNP measurement. Primary endpoints were positive predictive values of age-stratified cutoffs (450, 900, and 1,800 pg/ml) for diagnosis of acute HF and negative predictive value of the rule-out cutoff to exclude acute HF. Secondary endpoints included sensitivity, specificity, and positive (+) and negative (−) likelihood ratios (LRs) for acute HF. Results Of 1,461 subjects, 277 (19%) were adjudicated as having acute HF. The area under the receiver-operating characteristic curve for diagnosis of acute HF was 0.91 (95% confidence interval [CI]: 0.90 to 0.93; p < 0.001). Sensitivity for age stratified cutoffs of 450, 900, and 1,800 pg/ml was 85.7%, 79.3%, and 75.9%, respectively; specificity was 93.9%, 84.0%, and 75.0%, respectively. Positive predictive values were 53.6%, 58.4%, and 62.0%, respectively. Overall LR+ across age-dependent cutoffs was 5.99 (95% CI: 5.05 to 6.93); individual LR+ for age-dependent cutoffs was 14.08, 4.95, and 3.03, respectively. The sensitivity and negative predictive value for the rule-out cutoff of 300 pg/ml were 93.9% and 98.0%, respectively; LR− was 0.09 (95% CI: 0.05 to 0.13). Conclusions In acutely dyspneic patients seen in the ED setting, age-stratified NT-proBNP cutpoints may aid in the diagnosis of acute HF. An NT-proBNP <300 pg/ml strongly excludes the presence of acute HF

Monetary discounting and ventral striatal dopamine receptor availability in nontreatment-seeking alcoholics and social drinkers

RATIONALE: Dopamine (DA) in the ventral striatum (VST) has long been implicated in addiction pathologies, yet its role in temporal decision-making is not well-understood. OBJECTIVES: To determine if VST DA D2 receptor availability corresponds with greater impulsive choice in both nontreatment-seeking alcoholics (NTS) and social drinkers (SD). METHODS: NTS subjects (n = 10) and SD (n = 13) received PET scans at baseline with the D2/D3 radioligand [(11)C]raclopride (RAC). Outside the scanner, subjects performed a delay discounting procedure with monetary rewards. RAC binding potential (BPND) was estimated voxelwise, and correlations were performed to test for relationships between VST BPND and delay discounting performance. Self-reported impulsivity was also tested for correlations with BPND. RESULTS: Across all subjects, greater impulsive choice for $20 correlated with lower BPND in the right VST. NTS showed greater impulsive choice than SD and were more impulsive by self-report. Across all subjects, the capacity of larger rewards to reduce impulsive choice (the magnitude effect) correlated negatively (p = 0.028) with problematic alcohol use (AUDIT) scores. Self-reported impulsivity did not correlate with BPND in VST. CONCLUSIONS: Preference for immediate reinforcement may reflect greater endogenous striatal DA or lower D2 number, or both. Alcoholic status did not mediate significant effects on VST BPND, suggesting minimal effects from alcohol exposure. The apparent lack of BPND correlation with self-reported impulsivity highlights the need for objective behavioral assays in the study of the neurochemical substrates of behavior. Finally, our results suggest that the magnitude effect may be more sensitive to alcohol-induced problems than single discounting measures

A molecular cell biology toolkit for the study of meiosis in the silkworm Bombyx mori

Meiosis is usually described as 4 essential and sequential processes: (1) homolog pairing; (2) synapsis, mediated by the synaptonemal complex; (3) crossing over; and (4) segregation. In this canonical model, the maturation of crossovers into chiasmata plays a vital role in holding homologs together and ensuring their segregation at the first meiotic division. However, Lepidoptera (moths and butterflies) undergo 3 distinct meiotic processes, only one of which is canonical. Lepidoptera males utilize 2 meiotic processes: canonical meiosis that produces nucleated fertile sperm, and a noncanonical meiosis that produces anucleated nonfertile sperm which are nonetheless essential for reproduction. Lepidoptera females, which carry heteromorphic sex chromosomes, undergo a completely achiasmate (lacking crossovers) meiosis, thereby requiring an alternative mechanism to ensure proper homolog segregation. Here, we report that the development of a molecular cell biology toolkit designed to properly analyze features of meiosis, including the synaptonemal complex structure and function, in the silkworm Bombyx mori. In addition to standard homology searches to identify Bombyx orthologs of known synaptonemal complex encoding genes, we developed an ortholog discovery app (Shinyapp) to identify Bombyx orthologs of proteins involved in several meiotic processes. We used this information to clone genes expressed in the testes and then created antibodies against their protein products. We used the antibodies to confirm the localization of these proteins in normal male spermatocytes, as well as using in vitro assays to confirm orthologous interactions. The development of this toolkit will facilitate further study of the unique meiotic processes that characterize meiosis in Lepidoptera.</p